Research Focus
We study how clinical biomarkers interact as a system rather than as isolated variables.
After performing over 1,000 surgeries per year as a urologist, our research has shifted toward understanding clinical data through network-based and discrete mathematical approaches.
Our work focuses on testosterone, aging, inflammation, and renal function as interconnected systems that define clinical phenotypes.
Current Research
This section outlines our ongoing research projects. Information regarding clinical study disclosures and opt-out procedures is also provided.
Research Background
This section provides a clear and accessible overview of the research conducted in this laboratory, including our conceptual approach to disease and its scientific significance.
-
Mapping Triadic Motifs in Urology
Identifying reproducible three-symptom network structures across complex urological and urogynecological phenotypes using high-order discrete mathematics and clinical data.
-
Data-Driven Optimized Laser Therapeutic Design
Utilizing high-volume surgical data and longitudinal outcomes to computationally optimize non-ablative Er:YAG laser therapy pathways for personalized medicine.
-
Testosterone Within Systemic Aging Networks
Redefining testosterone deficiency as a coordinated, data-driven biological state characterized by non-linear interactions with systemic inflammation and renal function.
-
Decoding Patient Narratives Using NLP
Applying natural language processing and graph theory to extract structured clinical information from large-scale patient-generated text in real-world settings.
-
System-Level Approach to Functional Frailty
Understanding frailty not as a collection of symptoms, but as a dynamic reorganization of a multi-domain structured biomarker network.
-
Redefining Medicine as Structured Experience
Establishing a powerful interface between quantitative clinical precision and the rich spectrum of qualitative patient experience through structural transformation modeling.
Research Results
Please see our research results published as academic papers.
Principal Investigator
Nobuo Okui, MD, PhD
Professor of Innovation and Longevity Medicine, Juntendo University
Professor of Data Science, Kanagawa Dental University
President, The 22nd Annual Meeting of the Japanese Society for Men’s Health (2022)
Contact
Direct Laboratory Line: +81-46-897-9061
Yokosuka Women’s Urology & Urology Clinic
If this research succeeds, it could open the door to a new future in medicine.
Medicine and AI converge to redefine diseases as structured relational networks derived from patient narratives beyond traditional symptom-based clinical frameworks











